Article
Effects of hepatitis C virus on suppressor of cytokine signaling mRNA levels: comparison between different genotypes and core protein sequence analysis.
Journal of medical virology - 1 Jun 2011
Pascarella Stéphanie, Clément Sophie, Guilloux Kévin, Conzelmann Stéphanie, Penin François, Negro Francesco
Abstract excerpt
Glucose metabolism disturbances, including insulin resistance and type 2 diabetes, are frequent and important cofactors of hepatitis C. Increasing epidemiological and experimental data suggest that all major genotypes of hepatitis C virus (HCV), albeit to a different extent, cause insulin resistance. The HCV core protein has been shown to be sufficient to impair insulin signaling in vitro through several...
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