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Article

Direct involvement of the TEN domain at the active site of human telomerase.

Nucleic acids research - 1 Mar 2011

Jurczyluk Julie, Nouwens Amanda S, Holien Jessica K, Adams Timothy E, Lovrecz George O, Parker Michael W, Cohen Scott B, Bryan Tracy M

Abstract excerpt

Telomerase is a ribonucleoprotein that adds DNA to the ends of chromosomes. The catalytic protein subunit of telomerase (TERT) contains an N-terminal domain (TEN) that is important for activity and processivity. Here we describe a mutation in the TEN domain of human TERT that results in a greatly increased primer K(d), supporting a role for the TEN domain in DNA affinity. Measurement of enzyme kinetic parameters...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21051362
DOI: 10.1093/nar/gkq1083
PMCID: PMC3061064

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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