Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.

doi:10.1086/657418

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Article

Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.

The Journal of infectious diseases - 15 Dec 2010

Barkhash Andrey V, Perelygin Andrey A, Babenko Vladimir N, Myasnikova Natalia G, Pilipenko Pavel I, Romaschenko Aida G, Voevoda Mikhail I, Brinton Margo A

Abstract excerpt

The 2'-5'-oligoadenylate synthetase (2'-5'-OAS) family members are interferon-induced antiviral proteins. Twenty-three single nucleotide polymorphisms located within the OAS1, OAS2, OAS3, and OASL genes were analyzed in 142 patients with Russian tick-borne encephalitis. Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762,...

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Identifiers

PMID: 21050126
DOI: 10.1086/657418

Genes

OAS2
OAS3
OAS1
OASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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