Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS.

Cellular microbiology - 1 Sept 2007

Zhang Yue, Deng Qing, Porath Jaclyn A, Williams Carol L, Pederson-Gulrud Kristin J, Barbieri Joseph T

Abstract excerpt

Pseudomonas aeruginosa ExoS (453 amino acids) is a bifunctional type III cytotoxin, comprising a Rho GTPase-activating protein domain (RhoGAP), and a 14-3-3 dependent ADP-ribosyltransferase domain. In addition, ExoS contains a membrane localization domain (termed MLD, residues 51-77) which localizes and traffics ExoS within intoxicated host cells. While membrane localization has been shown to be essential for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP Ribose Transferases
Share to Bacterial Toxins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Membrane

Share to Cytotoxins

Share to GTPase-Activating Proteins

Share to HeLa Cells

Share to Pseudomonas aeruginosa

Share to Substrate Specificity

Source

Identifiers

PMID: 17490406
DOI: 10.1111/j.1462-5822.2007.00949.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS.PMID 17490406Read ↗

A leucine-rich motif targets Pseudomonas aeruginosa ExoS within mammalian cells.Semantic proximity Read ↗

Examination of the coordinate effects of Pseudomonas aeruginosa ExoS on Rac1.Semantic proximity Read ↗

Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 regulator of kinase (Crk) proteins.Semantic proximity Read ↗

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.Semantic proximity Read ↗

Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.Semantic proximity Read ↗

Independent and coordinate effects of ADP-ribosyltransferase and GTPase-activating activities of exoenzyme S on HT-29 epithelial cell function.Semantic proximity Read ↗

Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion.Semantic proximity Read ↗

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.Semantic proximity Read ↗

Expression ofPseudomonas aeruginosaToxin ExoS Effectively Induces Apoptosis in Host CellsSemantic proximity Read ↗

RNAi Screen Reveals an Abl Kinase-Dependent Host Cell Pathway Involved in Pseudomonas aeruginosa InternalizationSemantic proximity Read ↗

ADP-ribosylation by exoenzyme T of Pseudomonas aeruginosa induces an irreversible effect on the host cell cytoskeleton in vivo.Semantic proximity Read ↗

In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.