Article
Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.
American journal of physiology. Heart and circulatory physiology - 1 Mar 2002
Zimmer Thomas, Bollensdorff Christian, Haufe Volker, Birch-Hirschfeld Eckhard, Benndorf Klaus
Abstract excerpt
We isolated two full-length cDNA clones from the adult murine heart that encode two different voltage-gated Na+ channels: mH1 and mH2. Sequence comparisons indicated that mH1 is highly homologous to rat SCN5A, whereas mH2 is highly homologous to SCN4A, expressed in rat skeletal muscle. Electrophysiological properties of mH1 channels strongly resembled the tetrodotoxin (TTX)-resistant Na+ current of mouse...
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