Article
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin.
Biochemistry - 19 Jan 1993
Lomas D A, Evans D L, Stone S R, Chang W S, Carrell R W
Abstract excerpt
A major feature of the structure of alpha 1-antitrypsin is a five-stranded A-sheet into which the reactive center loop inserts after cleavage. We describe here the effect of the Z mutation (342Glu to Lys) at the head of the fifth strand of the A-sheet on the mobility of the reactive center loop and hence on the physical properties of the antitrypsin molecule. The mutant Z but not the normal M antitrypsin...
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