Article
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin.
Biochemistry - 19 Jan 1993
Lomas D A, Evans D L, Stone S R, Chang W S, Carrell R W
Abstract excerpt
A major feature of the structure of alpha 1-antitrypsin is a five-stranded A-sheet into which the reactive center loop inserts after cleavage. We describe here the effect of the Z mutation (342Glu to Lys) at the head of the fifth strand of the A-sheet on the mobility of the reactive center loop a...
Topics
- Amino Acid Sequence
- Binding Sites
- Chymotrypsin
- Circular Dichroism
- Hot Temperature
- Humans
- Hydrolysis
- Kinetics
- Leukocyte Elastase
- Molecular Sequence Data
- Mutation
- Pancreatic Elastase
- Polymers
- alpha 1-Antitrypsin