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Pulicatins A−E, Neuroactive Thiazoline Metabolites from Cone Snail-Associated Bacteria

28 Oct 2010

Abstract excerpt

The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca(2+) flux. These compounds include known thiazoline compounds and a series...

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PMID: 21028889
DOI: 10.1021/np100588c

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