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Introduction of marine-derivedStreptomycessp. UTMC 1334 as a source of pyrrole derivatives with anti-acetylcholinesterase activity

7 Jul 2018

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia. The acetylcholinesterase (AChE) inhibitors are the most viable therapeutic target for its symptomatic treatment. The present study was aimed at exploring anti‐AChE metabolite producing marine Actinobacteria. Of 220 isolates, 34 Actinobacteria extracts were tested for the presence of AChE inhibitors. The obtained results showed that bacterial strain...

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PMID: 29981531
DOI: 10.1111/jam.14043

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