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Depsipeptide Companeramides from a Panamanian Marine Cyanobacterium Associated with the Coibamide Producer

6 Jan 2015

Abstract excerpt

Two new cyclic depsipeptides, companeramides A (1) and B (2), have been isolated from the phylogenetically characterized cyanobacterial collection that yielded the previously reported cancer cell toxin coibamide A (collected from Coiba Island, Panama). The planar structures of the companeramides, which contain 3-amino-2-methyl-7-octynoic acid (Amoya), hydroxy isovaleric acid (Hiva), and eight α-amino acid units,...

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PMID: 25562664
DOI: 10.1021/np5007907

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