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Miuramides A and B, Trisoxazole Macrolides from a Mycale sp. Marine Sponge That Induce a Protrusion Phenotype in Cultured Mammalian Cells.

Journal of natural products - 27 Apr 2018

Suo Rei, Takada Kentaro, Kohtsuka Hisanori, Ise Yuji, Okada Shigeru, Matsunaga Shigeki

Abstract excerpt

Morphology-guided cell-based screening of the extract of a Mycale sp. marine sponge led to the isolation of two trisoxazole macrolides, miuramides A (1) and B (2), which induced characteristic morphological changes in 3Y1 cells. The structure of 1 including absolute configuration was elucidated by a combination of the analysis of spectroscopic data, derivatization, and degradation. Both compounds exhibit potent...

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PMID: 29613787
DOI: 10.1021/acs.jnatprod.8b00101

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