Article
Serological and molecular studies of HLA in insulin-dependent diabetes mellitus in Sardinia.
Disease markers - 1 Jan 2000
La Nasa G, Carcassi C, Cirillo R, Mulargia M, Leone A L, Vacca A, Pizzati A, Boero R, Arras M, Porcella R
Abstract excerpt
This study was carried out in Sardinia, an Italian region with a very high IDDM incidence. HLA class I and class II antigens were studied in 97 unrelated IDDM patients, 33 complete families with at least one affected member each, and 559 healthy controls. Molecular typing of the DQB1 alleles was...
Topics
- Alleles
- Base Sequence
- Diabetes Mellitus, Type 1
- Gene Frequency
- Genetic Predisposition to Disease
- HLA Antigens
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR3 Antigen
- Haplotypes
- Humans
- Italy