Article
Serological and molecular studies of HLA in Sardinian patients with Graves' disease.
Disease markers - 1 Jan 2000
La Nasa G, Martino E, Carcassi C, Mulargia M, Floris L, Vacca A, Baldini G, Orrù S, Ledda A, Grasso L
Abstract excerpt
HLA Class I and Class II antigens were studied in 103 unrelated Sardinian patients with Graves' disease (GD), 71 of whom had ophthalmopathy, and in 220 healthy controls. Molecular typing of the DQB1 allelic variants was carried out on 34 GD patients and 35 healthy controls, selected for the HLA-DR2-DQw1 phenotype. The results of the serological typing showed a positive association with the DR2 and the DQw1...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Base Sequence
- DNA
- DNA Probes, HLA
- Female
- Gene Frequency
- Genetic Markers
- Graves Disease