Article
Pancreatic cancer biology and genetics from an evolutionary perspective.
Nature reviews. Cancer - 1 Sept 2016
Makohon-Moore Alvin, Iacobuzio-Donahue Christine A
Abstract excerpt
Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma (hereafter referred to as pancreatic cancer) is a particularly robust example of this phenomenon. Genomic features indicate that pancreatic cancer cells are selected for fitness advantages when encountering the geographic and...
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