Mutations of <i>NPM1</i> gene in <i>de novo</i> acute myeloid leukaemia: determination of incidence, distribution pattern and identification of two novel mutations in Indian population

Abstract excerpt

Mutations in the nucleophosmin (NPM1) gene have been recently described to occur in about one-third of acute myeloid leukaemias (AMLs) and represent the most frequent genetic alteration currently known in this subset, specially in those with normal karyotype. This study explored the prevalence and clinical profile of NPM1 mutations in a cohort of 200 Indian adult and children with AML. NPM1 mutations were...

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