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Article

Selective macrophage ascorbate deficiency suppresses early atherosclerosis.

Free radical biology & medicine - 1 Jan 2011

Babaev Vladimir R, Whitesell Richard R, Li Liying, Linton MacRae F, Fazio Sergio, May James M

Abstract excerpt

To test whether severe ascorbic acid deficiency in macrophages affects progression of early atherosclerosis, we used fetal liver cell transplantation to generate atherosclerosis-prone apolipoprotein E-deficient (apoE(-/-)) mice that selectively lacked the ascorbate transporter (SVCT2) in hematopoietic cells, including macrophages. After 13 weeks of chow diet, apoE(-/-) mice lacking the SVCT2 in macrophages had...

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Identifiers

PMID: 20974251
DOI: 10.1016/j.freeradbiomed.2010.10.702
PMCID: PMC3014415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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