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Article

Aortic wall damage in mice unable to synthesize ascorbic acid.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000

Maeda N, Hagihara H, Nakata Y, Hiller S, Wilder J, Reddick R

Abstract excerpt

By inactivating the gene for L-gulono-gamma-lactone oxidase, a key enzyme in ascorbic acid synthesis, we have generated mice that, like humans, depend on dietary vitamin C. Regular chow, containing about 110 mg/kg of vitamin C, is unable to support the growth of the mutant mice, which require L-ascorbic acid supplemented in their drinking water (330 mg/liter). Upon withdrawal of supplementation, plasma and tissue...

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Identifiers

PMID: 10639167
DOI: 10.1073/pnas.97.2.841
PMCID: PMC15418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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