Article
POSH promotes cell survival in Drosophila and in human RASF cells.
FEBS letters - 19 Nov 2010
Tsuda Manabu, Kawaida Reimi, Kobayashi Kyoko, Shinagawa Akira, Sawada Tetsuji, Yamada Ryo, Yamamoto Kazuhiko, Aigaki Toshiro
Abstract excerpt
In Drosophila, Eiger, a tumor necrosis factor α (TNFα) superfamily ligand, induces cell death by activating the c-Jun N-terminal kinase (JNK) pathway. Here, we report that overexpression of Plenty of SH3s (POSH) suppresses Eiger-induced cell death and produces highly deformed tissues. These results imply that high levels of POSH protect tissues from cell death. In humans, rheumatoid arthritis synovial fibroblasts...
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