Article
Interleukin-6⁻¹⁷⁴ and tumor necrosis factor α⁻³⁰⁸ polymorphisms enhance cytokine production by human macrophages exposed to respiratory viruses.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Dec 2010
Patel Janak A, Nair Sangeeta, Ochoa Eliana E, Huda Ruksana, Roberts Norbert J, Chonmaitree Tasnee
Abstract excerpt
Interleukin-6⁻¹⁷⁴ (IL-6⁻¹⁷⁴) and tumor necrosis factor α⁻³⁰⁸ (TNFα⁻³⁰⁸) are high-cytokine-producing genotypes that are known to increase the susceptibility to infectious diseases, but their influence on cytokine production induced by respiratory viruses is unknown. We exposed human monocyte-derived macrophages from IL-6⁻¹⁷⁴, TNFα⁻³⁰⁸, and normal genotype donors to different respiratory viruses. Respiratory...
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