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Article

TNF, IL6, and IL1B Polymorphisms Are Associated with Severe Influenza A (H1N1) Virus Infection in the Mexican Population.

PloS one - 1 Jan 2015

García-Ramírez Román Alejandro, Ramírez-Venegas Alejandra, Quintana-Carrillo Roger, Camarena Ángel Eduardo, Falfán-Valencia Ramcés, Mejía-Aranguré Juan Manuel

Abstract excerpt

BACKGROUND: Hypercytokinemia is the main immunopathological mechanism contributing to a more severe clinical course in influenza A (H1N1) virus infections. Most patients infected with the influenza A (H1N1) pdm09 virus had increased systemic levels of pro-inflammatory cytokines; including interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). We propose that single-nucleotide polymorphisms (SNPs) in the...

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Source

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Identifiers

PMID: 26657940
DOI: 10.1371/journal.pone.0144832
PMCID: PMC4682834

Genes

TNF
CCL1
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TNF, IL6, and IL1B Polymorphisms Are Associated with Severe Influenza A (H1N1) Virus Infection in the Mexican Population.PMID 26657940Read ↗

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