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Article

Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells.

Journal of leukocyte biology - 1 Jan 2011

Martinez-Navio José M, Casanova Víctor, Pacheco Rodrigo, Naval-Macabuhay Isaac, Climent Núria, Garcia Felipe, Gatell José M, Mallol Josefa, Gallart Teresa, Lluis Carme, Franco Rafael

Abstract excerpt

By interacting with CD26 on the CD4+ T cell surface and with the AdoR A(₂B) on the DC surface, ADA triggers a costimulatory signal for human T cells. The aim of this study was to know whether ADA-mediated costimulation plays a role in the differentiation of T cells. The results show that irrespec...

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Source

Identifiers

PMID: 20959412
DOI: 10.1189/jlb.1009696

Genes

ADA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20959412-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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