Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

19 Oct 2010

Abstract excerpt

BACKGROUND: Pim family kinases are small constitutively active serine/threonine-specific kinases, elevated levels of which have been detected in human hematopoietic malignancies as well as in solid tumours. While we and others have previously shown that the oncogenic Pim kinases stimulate survival of hematopoietic cells, we now examined their putative role in regulating motility of adherent cancer cells. For this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Mechanisms of cancer metastasis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20958956
DOI: 10.1186/1476-4598-9-279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasionPMID 20958956Read ↗

Targeting PIM Kinases to Overcome Therapeutic Resistance in CancerSemantic proximity Read ↗

The PIM kinases in hematological cancersSemantic proximity Read ↗

A review on PIM kinases in tumorsSemantic proximity Read ↗

Protein kinase PIM2: A simple PIM family kinase with complex functions in cancer metabolism and therapeuticsSemantic proximity Read ↗

Fighting Tumor Cell Survival: Advances in the Design and Evaluation of Pim InhibitorsSemantic proximity Read ↗

Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity.Semantic proximity Read ↗

Why Target PIM1 for Cancer Diagnosis and Treatment?Semantic proximity Read ↗

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunitiesSemantic proximity Read ↗

Tricyclic Benzo[cd]azulenes Selectively Inhibit Activities of Pim Kinases and Restrict Growth of Epstein-Barr Virus-Transformed CellsSemantic proximity Read ↗

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterusSemantic proximity Read ↗

PIM1 kinase as a target for cancer therapySemantic proximity Read ↗

Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.