Article
Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity.
PloS one - 25 Feb 2010
Jambou Ronan, Martinelli Axel, Pinto João, Gribaldo Simonetta, Legrand Eric, Niang Makhtar, Kim Nimol, Pharath Lim, Volnay Béatrice, Ekala Marie Therese, Bouchier Christiane, Fandeur Thierry, Berzosa Pedro, Benito Agustin, Ferreira Isabel Dinis, Ferreira Cynthia, Vieira Pedro Paulo, Alecrim Maria das Graças, Mercereau-Puijalon Odile, Cravo Pedro
Abstract excerpt
Artemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted a sequence analysis of 100 isolates from multiple sites in Africa, Asia and South America. Coding...
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