Article
Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy.
Malaria journal - 8 Dec 2010
Gama Bianca E, de Oliveira Natália K Almeida, de Souza José M, Santos Fátima, de Carvalho Leonardo J M, Melo Yonne F C, Rosenthal Philip J, Daniel-Ribeiro Cláudio T, Ferreira-da-Cruz Maria de Fátima
Abstract excerpt
BACKGROUND: This study was performed to better understand the genetic diversity of known polymorphisms in pfatpase6 and pfmdr1 genes before the introduction of ACT in Brazil, in order to get a genotypic snapshot of Plasmodium falciparum parasites that may be used as baseline reference for future studies. METHODS: Parasites from P. falciparum samples collected in 2002, 2004 and 2006-2007 were genotyped using PCR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.