Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heat shock factor 1 protects mice from rapid death during Listeria monocytogenes infection by regulating expression of tumor necrosis factor alpha during fever.

Infection and immunity - 1 Jan 2011

Murapa Patience, Ward Martin R, Gandhapudi Siva K, Woodward Jerold G, D'Orazio Sarah E F

Abstract excerpt

Heat shock factor 1 (HSF1) is a stress-induced transcription factor that promotes expression of genes that protect mammalian cells from the lethal effects of severely elevated temperatures (>42°C). However, we recently showed that HSF1 is activated at a lower temperature (39.5°C) in T cells, sugg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Fever
Share to Heat Shock Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Listeria monocytogenes

Share to Listeriosis

Share to Lymphocyte Activation

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 20956571
DOI: 10.1128/IAI.00742-09
PMCID: PMC3019880

Genes

HSF1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20956571-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heat shock factor 1 protects mice from rapid death during Listeria monocytogenes infection by regulating expression of tumor necrosis factor alpha during fever.PMID 20956571Read ↗

Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity.Semantic proximity Read ↗

Heat Shock Factor Regulation of Antimicrobial Peptides Expression Suggests a Conserved Defense Mechanism Induced by Febrile Temperature in ArthropodsSemantic proximity Read ↗

HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice.Semantic proximity Read ↗

Fever enhances host bacterial defense while limiting mitochondrial damageSemantic proximity Read ↗

HSF1 is a transcriptional activator of IL-10 gene expression in RAW264.7 macrophages.Semantic proximity Read ↗

PDCD1 expression increases at elevated temperaturesSemantic proximity Read ↗

A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor.Semantic proximity Read ↗

Hyperthermia Stimulates HIV-1 ReplicationSemantic proximity Read ↗

Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis.Semantic proximity Read ↗

Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures.Semantic proximity Read ↗

Heat shock response pathways regulate stimulus-specificity and sensitivity of NF-κB signalling to temperature stressSemantic proximity Read ↗

Olfactory learning primes the heat shock transcription factor HSF-1 to enhance the expression of molecular chaperone genes in <i>C. elegans</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.