Article
Admixture mapping of end stage kidney disease genetic susceptibility using estimated mutual information ancestry informative markers.
BMC medical genomics - 18 Oct 2010
Shlush Liran I, Bercovici Sivan, Wasser Walter G, Yudkovsky Guennady, Templeton Alan, Geiger Dan, Skorecki Karl
Abstract excerpt
BACKGROUND: The question of a genetic contribution to the higher prevalence and incidence of end stage kidney disease (ESKD) among African Americans (AA) remained unresolved, until recent findings using admixture mapping pointed to the association of a genomic locus on chromosome 22 with this disease phenotype. In the current study we utilize this example to demonstrate the utility of applying a multi-step...
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