Article
Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta.
PloS one - 1 Jan 2013
Madar Shalom, Harel Einav, Goldstein Ido, Stein Yan, Kogan-Sakin Ira, Kamer Iris, Solomon Hilla, Dekel Elya, Tal Perry, Goldfinger Naomi, Friedlander Gilgi, Rotter Varda
Abstract excerpt
Mutations in the p53 tumor suppressor protein are highly frequent in tumors and often endow cells with tumorigenic capacities. We sought to examine a possible role for mutant p53 in the cross-talk between cancer cells and their surrounding stroma, which is a crucial factor affecting tumor outcome. Here we present a novel model which enables individual monitoring of the response of cancer cells and stromal cells...
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