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Article

Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase.

The Journal of biological chemistry - 31 Dec 2010

Jeanguenin Linda, Lara-Núñez Aurora, Pribat Anne, Mageroy Melissa Hamner, Gregory Jesse F, Rice Kelly C, de Crécy-Lagard Valérie, Hanson Andrew D

Abstract excerpt

5-Formyltetrahydrofolate (5-CHO-THF) is formed by a side reaction of serine hydroxymethyltransferase. Unlike other folates, it is not a one-carbon donor but a potent inhibitor of folate enzymes and must therefore be metabolized. Only 5-CHO-THF cycloligase (5-FCL) is generally considered to do this. However, comparative genomic analysis indicated (i) that certain prokaryotes lack 5-FCL, implying that they have an...

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PMID: 20952389
DOI: 10.1074/jbc.M110.190504
PMCID: PMC3009883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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