Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves.

The Journal of biological chemistry - 15 Jul 2005

Goyer Aymeric, Collakova Eva, Díaz de la Garza Rocío, Quinlivan Eoin P, Williamson Jerry, Gregory Jesse F, Shachar-Hill Yair, Hanson Andrew D

Abstract excerpt

5-Formyltetrahydrofolate (5-CHO-THF) is formed via a second catalytic activity of serine hydroxymethyltransferase (SHMT) and strongly inhibits SHMT and other folate-dependent enzymes in vitro. The only enzyme known to metabolize 5-CHO-THF is 5-CHO-THF cycloligase (5-FCL), which catalyzes its conversion to 5,10-methenyltetrahydrofolate. Because 5-FCL is mitochondrial in plants and mitochondrial SHMT is central to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbon Dioxide
Share to Carbon-Nitrogen Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycine

Share to Glycine Hydroxymethyltransferase

Share to Hydrolysis

Share to Leucovorin

Share to Models, Chemical

Share to Tetrahydrofolates

Source

Identifiers

PMID: 15888445
DOI: 10.1074/jbc.M503106200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves.PMID 15888445Read ↗

Arabidopsis 10-formyl tetrahydrofolate deformylases are essential for photorespiration.Semantic proximity Read ↗

The presequence of Arabidopsis serine hydroxymethyltransferase SHM2 selectively prevents import into mesophyll mitochondria.Semantic proximity Read ↗

Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana.Semantic proximity Read ↗

Functional analysis of folate polyglutamylation and its essential role in plant metabolism and development.Semantic proximity Read ↗

Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase.Semantic proximity Read ↗

Folate metabolism in plants: an Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts.Semantic proximity Read ↗

Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.Semantic proximity Read ↗

Enzymatic regulation of methionine/homocysteine levels by the folate pathway dictates broad-spectrum defense in Arabidopsis.Semantic proximity Read ↗

Pterin and folate salvage. Plants and Escherichia coli lack capacity to reduce oxidized pterins.Semantic proximity Read ↗

The cytosolic branched-chain aminotransferases of Arabidopsis thaliana influence methionine supply, salvage and glucosinolate metabolism.Semantic proximity Read ↗

Folate polyglutamylation is involved in chromatin silencing by maintaining global DNA methylation and histone H3K9 dimethylation in Arabidopsis.Semantic proximity Read ↗

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.