Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1.

doi:10.1093/genetics/158.1.109

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Article

Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1.

Genetics - 1 May 2001

Rattray A J, McGill C B, Shafer B K, Strathern J N

Abstract excerpt

Errors associated with the repair of DNA double-strand breaks (DSBs) include point mutations caused by misincorporation during repair DNA synthesis or novel junctions made by nonhomologous end joining (NHEJ). We previously demonstrated that DNA synthesis is approximately 100-fold more error prone when associated with DSB repair. Here we describe a genetic screen for mutants that affect the fidelity of DSB repair....

Topics

DNA Damage
DNA Repair
Endonucleases
Fungal Proteins
Haploidy
Mitosis
Mutation
Phenotype
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 11333222
DOI: 10.1093/genetics/158.1.109
PMCID: PMC1461648

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