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Article

YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors.

Endocrine-related cancer - 1 Apr 2014

Fu David, Lv Xiangmin, Hua Guohua, He Chunbo, Dong Jixin, Lele Subodh M, Li David Wan-Cheng, Zhai Qiongli, Davis John S, Wang Cheng

Abstract excerpt

The Hippo signaling pathway has been implicated as a conserved regulator of organ size in both Drosophila and mammals. Yes-associated protein (YAP), the central component of the Hippo signaling cascade, functions as an oncogene in several malignancies. Ovarian granulosa cell tumors (GCT) are characterized by enlargement of the ovary, excess production of estrogen, a high frequency of recurrence, and the potential...

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Source

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Identifiers

PMID: 24389730
DOI: 10.1530/ERC-13-0339
PMCID: PMC4222524

Genes

YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors.PMID 24389730Read ↗

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Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosisSemantic proximity Read ↗

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The Hippo Pathway Effectors YAP and TAZ Regulate LH Release by Pituitary Gonadotrope Cells in Mice.Semantic proximity Read ↗

SMAD3 Activation: A Converging Point of Dysregulated TGF-Beta Superfamily Signaling and Genetic Aberrations in Granulosa Cell Tumor Development?Semantic proximity Read ↗

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