Article
Genetic variants conferring susceptibility to Alzheimer's disease in the general population; do they also predispose to dementia in Down's syndrome.
BMC research notes - 17 Jan 2014
Patel Ashok, Rees Simon D, Kelly M Ann, Bain Stephen C, Barnett Anthony H, Prasher Anisha, Arshad Humaria, Prasher Vee P
Abstract excerpt
BACKGROUND: Down's syndrome (DS) is caused by either complete or partial triplication of chromosome 21, affecting approximately 1/1000 live births, and it is widely accepted that individuals with DS are more likely to develop dementia of Alzheimer's disease (DAD) compared with the general population. Recent collaborative genome-wide association studies of large case control data sets of individuals with and...
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