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Article

Applying internal coordinate mechanics to model the interactions between 8R-lipoxygenase and its substrate.

BMC bioinformatics - 7 Oct 2010

Bai Shuju, Du Tianchuan, Khosravi Ebrahim

Abstract excerpt

BACKGROUND: Lipoxygenases (LOX) play pivotal roles in the biosynthesis of leukotrienes and other biologically active potent signalling compounds. Developing inhibitors for LOX is of high interest to researchers. Modelling the interactions between LOX and its substrate arachidonic acid is critical for developing LOX specific inhibitors. Currently, there are no LOX-substrate structures. Recently, the structure of a...

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Identifiers

PMID: 20946603
DOI: 10.1186/1471-2105-11-S6-S2
PMCID: PMC3026367

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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