Article
Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2010
Bonzo Jessica A, Patterson Andrew D, Krausz Kristopher W, Gonzalez Frank J
Abstract excerpt
Mutations in the HNF1A gene cause maturity-onset diabetes of the young type 3, one of the most common genetic causes of non-insulin-dependent (type 2) diabetes mellitus. Although the whole-body Hnf1a-null mouse recapitulates the low insulin levels and high blood glucose observed in human maturity-onset diabetes of the young type 3 patients, these mice also suffer from Laron dwarfism and aminoaciduria, suggesting...
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