Article
ARID1A protein expression is retained in ovarian endometriosis with ARID1A loss-of-function mutations: implication for the two-hit hypothesis.
Scientific reports - 31 Aug 2020
Yachida Nozomi, Yoshihara Kosuke, Suda Kazuaki, Nakaoka Hirofumi, Ueda Haruka, Sugino Kentaro, Yamaguchi Manako, Mori Yutaro, Yamawaki Kaoru, Tamura Ryo, Ishiguro Tatsuya, Isobe Masanori, Motoyama Teiichi, Inoue Ituro, Enomoto Takayuki
Abstract excerpt
ARID1A loss-of-function mutation accompanied by a loss of ARID1A protein expression is considered one of the most important driver events in endometriosis-associated ovarian cancer. Although our recent genomic study clarified that ARID1A loss-of-function mutations were detected in 13% of ovarian endometriosis, an association between the ARID1A mutation status and ARID1A protein expression in ovarian endometriosis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.