Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dopamine turnover increases in asymptomatic LRRK2 mutations carriers.

Movement disorders : official journal of the Movement Disorder Society - 15 Dec 2010

Sossi Vesna, de la Fuente-Fernández Raul, Nandhagopal Ramachandiran, Schulzer Michael, McKenzie Jessamyn, Ruth Thomas J, Aasly Jan O, Farrer Matthew J, Wszolek Zbigniew K, Stoessl Jon A

Abstract excerpt

Increase in dopamine (DA) turnover was found to occur early in symptomatic Parkinson's disease (PD) and to be functionally related to the dopamine transporter (DAT). The objectives of this study were to examine changes in DA turnover in the asymptomatic PD phase; to compare them with changes in other dopaminergic markers, and to investigate a possible relationship between DAT and DA turnover. Eight subjects from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dopamine

Share to Dopamine Plasma Membrane Transport Proteins

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Protein Serine-Threonine Kinases

Share to Radionuclide Imaging

Share to Statistics, Nonparametric

Source

Identifiers

PMID: 20939082
DOI: 10.1002/mds.23356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Dopamine turnover increases in asymptomatic LRRK2 mutations carriers.PMID 20939082Read ↗

PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.Semantic proximity Read ↗

DAT imaging and clinical biomarkers in relatives at genetic risk for LRRK2 R1441G Parkinson's disease.Semantic proximity Read ↗

Functional monoamine oxidase B gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson's disease.Semantic proximity Read ↗

Serial DaT-SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8 years' follow-up.Semantic proximity Read ↗

Cerebrospinal fluid amyloid β and tau in LRRK2 mutation carriers.Semantic proximity Read ↗

The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study.Semantic proximity Read ↗

A scan without evidence is not evidence of absence: Scans without evidence of dopaminergic deficit in a symptomatic leucine-rich repeat kinase 2 mutation carrier.Semantic proximity Read ↗

Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease.Semantic proximity Read ↗

Striatal glucose metabolism and dopamine D2 receptor binding in asymptomatic gene carriers and patients with Huntington's disease.Semantic proximity Read ↗

Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.