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Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease

1 Jul 1996

Abstract excerpt

We have investigated striatal dopamine D1 and D2 receptor binding in asymptomatic subjects from Huntington's disease (HD) families using positron emission tomography. Nineteen adult subjects at risk of developing HD were scanned with 11C-SCH 23390 and 11C-raclopride to calculate the D1 and D2 receptor binding potential, respectively. Eight of the 19 were shown to have the HD mutation; of these, 4 subjects had...

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PMID: 8687191
DOI: 10.1002/ana.410400110

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