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Article

Functional Maturation of the Human Antibody Response to Rotavirus

1 Mar 2008

Abstract excerpt

Infant Abs induced by viruses exhibit poor functional activity compared with those of adults. The human B cell response to rotavirus is dominated by use of the V(H)1-46 gene segment in both adults and infants, but only adult sequences are highly mutated. We investigated in detail the kinetic, structural, and functional advantage conferred by individual naturally occurring somatic mutations in rotavirus-specific...

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PMID: 18322207
DOI: 10.4049/jimmunol.180.6.3980

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