Article
Association analysis of UBE3C polymorphisms in Korean aspirin-intolerant asthmatic patients.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 Oct 2010
Lee Jin Sol, Kim Jeong-Hyun, Bae Joon Seol, Kim Jason Yongha, Park Tae Joon, Pasaje Charisse Flerida, Park Byung-Lae, Cheong Hyun Sub, Park Jong-Sook, Uh Soo-Taek, Kim Mi-Kyeong, Choi Inseon S, Cho Sang Heon, Choi Byoung Whui, Park Choon-Sik, Shin Hyoung Doo
Abstract excerpt
BACKGROUND: Aspirin-intolerant asthma (AIA), as an asthma phenotype that involves the upper or lower airways, occurs from excessive leukotriene production on administration of nonsteroidal anti-inflammatory drugs. The UBE3C gene on chromosome 7 is a member of the E3 ligase enzymes and is implicated in the ubiquitin-proteasome pathway. This pathway is involved in immune responses to inflammation, including asthma....
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