Article
Characterisation of the epitope for a herpes simplex virus glycoprotein B-specific monoclonal antibody with high protective capacity.
Medical microbiology and immunology - 1 May 2011
Däumer Martin P, Schneider Beate, Giesen Doris M, Aziz Sheriff, Kaiser Rolf, Kupfer Bernd, Schneweis Karl E, Schneider-Mergener Jens, Reineke Ulrich, Matz Bertfried, Eis-Hübinger Anna M
Abstract excerpt
Monoclonal antibody (MAb) 2c, specific for glycoprotein B of herpes simplex virus (HSV), had been shown to mediate clearance of infection from the mucous membranes of mice, thereby completely inhibiting mucocutaneous inflammation and lethality, even in mice depleted of both CD4(+) and CD8(+) cells. Additionally, ganglionic infection was highly restricted. In vitro, MAb 2c exhibits a potent complement-independent...
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