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Article

Mechanism of neutralization of herpes simplex virus by antibodies directed at the fusion domain of glycoprotein B.

Journal of virology - 1 Mar 2014

Cairns Tina M, Fontana Juan, Huang Zhen-Yu, Whitbeck J Charles, Atanasiu Doina, Rao Samhita, Shelly Spencer S, Lou Huan, Ponce de Leon Manuel, Steven Alasdair C, Eisenberg Roselyn J, Cohen Gary H

Abstract excerpt

UNLABELLED: Glycoprotein B (gB), the fusogen of herpes simplex virus (HSV), is a class III fusion protein with a trimeric ectodomain of known structure for the postfusion state. Seen by negative-staining electron microscopy, it presents as a rod with three lobes (base, middle, and crown). gB has four functional regions (FR), defined by the physical location of epitopes recognized by anti-gB neutralizing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24352457
DOI: 10.1128/JVI.03200-13
PMCID: PMC3958082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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