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Article

Restricted antigenic variability of the epitope recognized by the neutralizing gp41 antibody 2F5

1 Jun 1996

Abstract excerpt

OBJECTIVE: To investigate whether variations of the conserved gp41 amino-acid sequence ELDKWA affect its binding or neutralization by monoclonal antibody (MAb) 2F5. DESIGN AND METHODS: Neutralization assays were performed with primary isolates from different HIV-1 subtypes and the sequences corresponding to the 2F5 epitope region were analysed. Studies of MAb 2F5 peptide reactivity were performed by spot...

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PMID: 8780812
DOI: 10.1097/00002030-199606000-00003

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