Article
Non-coding RNA as a trigger of neuropathologic disorder phenotypes in transgenic Drosophila.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Dec 2008
Savvateeva-Popova Elena, Popov Andrej, Grossman Abraham, Nikitina Ekaterina, Medvedeva Anna, Molotkov Dmitry, Kamyshev Nicholas, Pyatkov Konstantin, Zatsepina Olga, Schostak Natalya, Zelentsova Elena, Pavlova Galina, Panteleev Dmitry, Riederer Peter, Evgen'ev Michail
Abstract excerpt
At most, many protein-misfolding diseases develop as environmentally induced sporadic disorders. Recent studies indicate that the dynamic interplay between a wide repertoire of noncoding RNAs and the environment play an important role in brain development and pathogenesis of brain disorders. To elucidate this new issue, novel animal models which reproduce the most prominent disease manifestations are required....
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