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Article

Polymorphisms of the hypoxia-inducible factor 1 gene and peripheral artery disease.

Vascular medicine (London, England) - 1 Oct 2010

Bahadori Babak, Uitz Elisabeth, Mayer Andreas, Harauer Jürgen, Dam Karl, Truschnig-Wilders Martini, Pilger Ernst, Renner Wilfried

Abstract excerpt

Hypoxia-inducible factor 1 (HIF1) is a key regulator of angiogenesis and is involved in inflammation, which are two important features of the pathogenesis of peripheral artery disease (PAD). The gene for the HIF1-alpha subunit (HIF1A) carries two common mis-sense mutations, P582S (C>T, rs11549465) and A588T (G>A, rs11549467), which both have been related to increased trans-activation capacity of HIF1-alpha. The...

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PMID: 20926496
DOI: 10.1177/1358863X10379674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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