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Article

Lack of association between hypoxia inducible factor-1 alpha gene polymorphisms and biopsy-proven giant cell arteritis.

Clinical and experimental rheumatology - 1 Jan 2000

Torres Orlando, Palomino-Morales Rogelio, Vazquez-Rodriguez Tomas R, Gamallo Carlos, Morado Immaculada C, Miranda-Filloy Jose A, Amigo-Diaz Encarnacion, Callejas-Rubio Jose L, Fernadez-Gutierrez Benjamin, Castañeda Santos, Morado Immaculada C, Martin Javier, Gonzalez-Gay Miguel A

Abstract excerpt

OBJECTIVES: Since the transcription factor hypoxia-inducible factor 1 (HIF-1) is a key early mediator of the response to ischemia and giant cell arteritis (GCA) is a polygenic disease leading to severe ischemic complications, in the present study we analysed for first time the implication of two HIF-1alpha gene polymorphisms in the susceptibility to and clinical expression of GCA. METHODS: Two hundred and fifteen...

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Source

Identifiers

PMID: 20412701

Genes

GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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