Article
A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasis.
Human heredity - 1 Jan 2010
Gui Jiang, Andrew Angeline S, Andrews Peter, Nelson Heather M, Kelsey Karl T, Karagas Margaret R, Moore Jason H
Abstract excerpt
Epistasis or gene-gene interaction is a fundamental component of the genetic architecture of complex traits such as disease susceptibility. Multifactor dimensionality reduction (MDR) was developed as a nonparametric and model-free method to detect epistasis when there are no significant marginal genetic effects. However, in many studies of complex disease, other covariates like age of onset and smoking status...
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