Article
Fluoxetine disposition in patients with chronic hepatitis C treated with interferon-α.
Clinical pharmacokinetics - 1 Nov 2010
Furlanut Mario, Soardo Giorgio, Donnini Debora, Sechi Leonardo, Franceschi Loretta
Abstract excerpt
BACKGROUND AND OBJECTIVES: Combination therapy with interferon-α and ribavirin is considered the treatment of choice for chronic hepatitis C. However, interferon-α may induce severe depression. It has been suggested that interferon-α is able to modify cytochrome P450 (CYP) 1A2 and 2D6 activity. W...
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