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Article

Inhibition by fluoxetine of cytochrome P450 2D6 activity.

Clinical pharmacology and therapeutics - 1 Apr 1993

Otton S V, Wu D, Joffe R T, Cheung S W, Sellers E M

Abstract excerpt

Potent inhibition of cytochrome P450 2D6 (CYP2D6) in human liver microsomes by fluoxetine and its major metabolite norfluoxetine was confirmed (apparent inhibition constant values, 0.2 mumol/L). Several other serotonergic agents were also found to be competitive inhibitors of this genetically pol...

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Source

Identifiers

PMID: 8477556
DOI: 10.1038/clpt.1993.43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8477556-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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