Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-1beta maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways.

Leukemia - 1 Oct 2004

Turzanski J, Grundy M, Russell N H, Pallis M

Abstract excerpt

Blast cell survival in suspension culture is associated with chemoresistance in acute myeloid leukaemia (AML). Autonomous production of IL-1beta by AML blasts is linked with a proliferative response, although its role in survival and hence apoptosis-resistance has not been examined in this disease. Cells that secreted more than 19.7 pg/ml IL-1beta were significantly more resistant to spontaneous apoptosis in 48-h...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Interleukin-1
Share to Interleukin-1 Receptor-Associated Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplastic Stem Cells

Share to NF-kappa B

Share to Phosphatidylinositol 3-Kinases

Share to Protein Kinases

Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 15306822
DOI: 10.1038/sj.leu.2403457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-1beta maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways.PMID 15306822Read ↗

Molecular Abnormalities in Chronic Myeloid Leukemia: Deregulation of Cell Growth and ApoptosisSemantic proximity Read ↗

Mcl-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cellsSemantic proximity Read ↗

FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanismSemantic proximity Read ↗

Control of apoptosis in hematopoiesis and leukemia by cytokines, tumor suppressor and oncogenes.Semantic proximity Read ↗

AT-101 induces apoptosis in CLL B cells and overcomes stromal cell–mediated Mcl-1 induction and drug resistanceSemantic proximity Read ↗

Roles of Bim in Apoptosis of Normal and Bcr-Abl-Expressing Hematopoietic ProgenitorsSemantic proximity Read ↗

Apoptosis Induced by the Kinase Inhibitor BAY 43-9006 in Human Leukemia Cells Involves Down-regulation of Mcl-1 through Inhibition of TranslationSemantic proximity Read ↗

Preferential induction of apoptosis of leukaemic cells by farnesolSemantic proximity Read ↗

Preferential induction of apoptosis for primary human leukemic stem cells.Semantic proximity Read ↗

Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase-3) expression in human leukemia cells.Semantic proximity Read ↗

Hematopoietic cytokines mediate resistance to targeted therapy in FLT3-ITD acute myeloid leukemiaSemantic proximity Read ↗

Editor's Note: Cotreatment with STI-571 Enhances Tumor Necrosis Factor α-related Apoptosis-inducing Ligand (TRAIL or Apo-2L)–induced Apoptosis of Bcr-Abl–positive Human Acute Leukemia CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.