Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent.

doi:10.4049/jimmunol.1001594

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Article

Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2010

Tregoning John S, Yamaguchi Yuko, Wang Belinda, Mihm Dagmar, Harker James A, Bushell Ellen S C, Zheng Ming, Liao Guochun, Peltz Gary, Openshaw Peter J M

Abstract excerpt

Respiratory syncytial virus (RSV) is a major cause of respiratory morbidity, resulting in hospitalization for bronchiolitis in some infected infants that is associated with wheeze in later life. Genetic factors are known to affect the severity of the sequelae after RSV infection, but the complexity of the temporal and genetic effects makes it difficult to analyze this response in studies in man. Therefore, we...

Topics

Animals
Animals, Congenic
Animals, Newborn
Asthma
Cell Separation
Chromosome Mapping
Disease Models, Animal
Flow Cytometry
Genetic Predisposition to Disease
Haplotypes
Major Histocompatibility Complex
Mice
Mice, Inbred BALB C

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Polymorphism, Single Nucleotide

Respiratory Sounds

Respiratory Syncytial Virus Infections

Respiratory Syncytial Viruses

Source

Open in PubMed

Identifiers

PMID: 20921522
DOI: 10.4049/jimmunol.1001594

Provenance

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