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Article

Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations.

Familial cancer - 1 Apr 2018

Wang Tao, Stadler Zsofia K, Zhang Liying, Weiser Martin R, Basturk Olca, Hechtman Jaclyn F, Vakiani Efsevia, Saltz Lenard B, Klimstra David S, Shia Jinru

Abstract excerpt

Microsatellite instability, a well-established driver pathway in colorectal carcinogenesis, can develop in both sporadic and hereditary conditions via different molecular alterations in the DNA mismatch repair (MMR) genes. MMR protein immunohistochemistry (IHC) is currently widely used for the detection of MMR deficiency in solid tumors. The IHC test, however, can show varied staining patterns, posing challenges...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28819720
DOI: 10.1007/s10689-017-0031-9
PMCID: PMC5908711

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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